Viral Vector Building Service

Gene therapy is a medical field in which cells are genetically modified to produce therapeutic effects by repairing or reconstructing defective genetic material. Viruses, as carriers of gene therapy, play an essential role in gene therapy, and their principle of action is to utilize viruses to deliver target genes into target cells and express target proteins.

Viral vectors are often used as gene delivery vehicles or tools for disease research due to their unique gene delivery characteristics and target specificity. All viral tools start with expression plasmid construction. Lifeasible can provide various viral plasmid construction and packaging services, providing you with multi-faceted gene delivery solutions and empowering gene medicine innovation and development.

• EB virus vector building service
• Herpes virus vector building service
• Poxvirus vector building service
• RNA virus vector building service
• Recombinant virus vector building service
• Ultra-large capacity viral vector building service
• Retroviral vector building service
• Lentiviral vector building service

With a wide host range, large genome capacity, random integration into the host genome, rapid and long-time stable expression, often used in cellular experiments, stable strain can be constructed.

• Adenovirus vector building service

Strong infectivity, large genome capacity, rapid and transient expression, often used in terminal differentiated cells and animal experiments.

• AAV vector building service

Extremely low immunogenicity, not integrated into the genome, stable expression for a long time, strong in vivo diffusion capacity, multiple serotypes, multi-tissue affinity, often used in animal experiments.

• Viral vector characterization and biosafety testing service

Service flow

Applications

• Gene function studies. Phenotyping of genes by combining the viral packaging system with the CRISPR system we provide for gene editing.
• Target protein expression. Construct cell lines that stably express target proteins, which are then introduced into animals for gene therapy.
• Pharmaceutical research. Construct cell lines expressing receptor proteins to study the effects of medicines.
• Transgenic animals. To construct transgenic animal models by transferring target genes into animal tissues for long-term expression of the target genes.

Viral vectors are the critical link for gene delivery and gene manipulation. With the help of viral vectors, overexpression, interference, knockdown, and endogenous activation of coding or non-coding genes can be performed. Due to their different infection characteristics, AAV, adenoviruses, lentiviruses, and retroviruses have different application scenarios in neurology, oncology, and metabolism. Please feel free to contact us with your needs.