The substance base of herbal medicine refers to the sum of all the active ingredients that contribute to the therapeutic effect of herbal medicine on disease and is the core and key to modernizing herbal medicine. Herbs are effective through the synergistic action of multiple active ingredients, but due to the complexity of the chemical composition of herbal medicines, the methodologies for the study of their potent substance bases are constantly being explored. The chemical composition of herbal medicines is a complex system, and the animal organism on which it acts is an even more complex system. Lifeasible uses serum medicinal chemistry, bionanotechnology, and spectrum-effect relationships to analyze the substance basis of herbal medicines in terms of their overall action, which can help you to identify the active ingredients of herbal medicines.
We use biotransformation technology to help you obtain substances rare in nature or novel chemical structures with activity at a lower cost, thus expanding your source options and facilitating the development of new herbal medicines.
We allow structural modification and structural optimization of different herbal chemical components based on different activities, which can improve their targeting and efficacy to improve the physicochemical properties of the herb, increase its biological activity or reduce its adverse effects.
We can use modern science and technology to conduct an in-depth analysis of the pharmacological basis, mechanism of action, and structure-activity relationship of herbal medicines, which is a crucial way to develop innovative drugs with independent intellectual property rights.
We use modern high-sensitive and high-resolution analytical techniques for the identification and analysis of chemical components and their contents and integrate various pharmacological methods for the analysis of the pharmacodynamic effects and interrelationships of the components of herbal compounding, to help you study the combination pattern of herbal compounding and elucidate the multi-targeting mechanism of regulation of herbal compounding.
Our bioequivalence analysis plays a vital role in drug development and evaluation. We can provide a holistic and comprehensive evaluation of the equivalence and equivalence of herbal medicines by examining them from multiple perspectives, levels, pathways, and indicators.
We provide pharmacokinetic analysis of herbal medicines to help you scientifically evaluate the pharmacokinetic characteristics of herbal medications in the body, reveal the material basis of their effects, and clarify the correlation between in vivo exposure and efficacy.
We can provide qualitative and quantitative analysis of herbal metabolite groups. We have developed techniques for analyzing biological samples in complex systems to enable the isolation and analysis of the substances to be tested.
We integrate herbal serum medicinal chemistry theory with metabolomics technology to establish a biological evaluation system for the efficacy of prescriptions based on the resolution of evidence-based biomarkers, which can help you to discover and identify the material basis of herbal efficacy.
We have developed a system of herbal genealogy by acquiring, processing, and mining information from herbal fingerprints, as well as researching the correlation between fingerprint information and pharmacological activity information, thus realizing the transformation of herbal chemical fingerprints into herbal pharmacological component fingerprints, and forming a system of herbal genealogy.
Lifeasible can help you to investigate the substance basis of herbal medicine by tracking the chemical separation of herbal compounds for active ingredients or groups of active ingredients or by simulating the metabolism of drugs in vivo. Please feel free to contact us for a bespoke solution.